Automated Direct Sample Analysis (DSA/TOF) for the Rapid Testing of Drug Compounds
نویسندگان
چکیده
Testing methods for drugs currently require long chromatographic methods and sample preparation or immunoassay techniques (EMIT) with confirmation by GC/MS or LC/MS/MS. These methods can be timeconsuming and laborious. The majority of urine testing methods cover only a limited number of metabolites, since reference standards are poorly available, making it difficult to keep up with the changing illicit drug scene. Due to the variety of compounds available, it is important to monitor the entire spectral range, which is easily performed using a time-of-flight-mass spectrometer (TOF MS). The ability to analyze samples rapidly is desirable, as drug seizures may result in thousands of samples. A method was developed using the AxION® 2 TOF MS integrated with the AxION Direct Sample AnalysisTM (DSATM) system (Figure 1) for testing various classes of street seized, illicit designer drugs, and growth hormones in solid, liquids as well as metabolites in urine.
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تاریخ انتشار 2014